My second post over at American Scientist’s renovated blog network tackles some of the latest thinking about a new process to target that is especially important for cancer cells. Targeting gene transcription– making mRNA from DNA genes– does a number on some of the nastiest types of cancer. Head over to my post to find out how and why.
@SnarkyScientistFollowers: 1663Feb 15, 2018 @ 10:12am
@jaybradner . @jaybradner: What if we could bring a pathogenic protein to the normal cell protein-degradation machinery with only a small molecule? Thalidomide, yes, that thalidomide, does it usually, so let's use parts of it to guide our targets to the cell's garbage disposal #KScancerepigenFeb 15, 2018 @ 10:01am
Last talk at #KScancerepigen: the inimitable @jaybradner to discuss his lab's (and companies') approaches to degrading transcription-regulating proteins. Why degrade? One pathogenic protein can have many functions, and we may need to block them all.
- The Academic Job Search — My Quest For a Fancier Title January 25, 2018
- Me vs. “MuTEs”: Enhancing Cancer’s Hallmarks via Mutation March 24, 2016
- Snarking the Science of Scorpion March 17, 2016
- Beating Cancers’ Unexpected Vice: Transcription – at AmericanScientist.org May 4, 2015
- Mutations that don’t break proteins – at AmericanScientist.org March 25, 2015
- Snarking Stem Cells: The Webinars February 8, 2015
- My Contribution to the ALS Ice Bucket Challenge — with Science! August 19, 2014
- How We Drugged a Leukemia’s Favorite Transcription Network August 11, 2014
- What is a stem cell? June 19, 2014
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